Zero to Birth - by William A Harris

About the Book

"By the time a baby is born, its brain has nearly 100 billion intricately shaped neurons wired together to comprise a small, soft-matter supercomputer. How is this incredibly complicated organ built in just nine months? This book is a step-by-step guide to what we know about the development of the human brain, from its earliest embryonic origin to birth and a little beyond. Written from an experimental neuroscientist's perspective, this book provides readers with a conceptual understanding of the field of developmental neurobiology, outlining both the biological mechanisms (genetic, environmental, and stochastic) that play significant and interrelated roles in neural development, and how we have come to understand the human brain's construction and function. Highlighting the major questions that have propelled the field forward-including those pushing at the frontiers of the field today-and the stories of major discoveries made by pioneering scientists around the world, the book describes how the structures and mechanisms of the developing brain were discovered. Chapters progress chronologically, tracking the actual growth and development of the human brain from conception to just after birth, as well as the history of how these mechanisms were revealed. Throughout, findings from studies of model organisms, such as nematodes, flies, frogs, fish, birds, mice, and sometimes non-human primates, are woven into the narrative and put into the context of a human embryo or fetus, as there are clear indications that the same processes involving the same genes are found across species. The book concludes with a discussion of what makes individual brains unique and how research on early neural development is helping us better understand the genetic and embryonic origins of many neurological and cognitive traits that only reveal themselves later in life"--

Book Synopsis

A revelatory tale of how the human brain develops, from conception to birth and beyond

By the time a baby is born, its brain is equipped with billions of intricately crafted neurons wired together through trillions of interconnections to form a compact and breathtakingly efficient supercomputer. Zero to Birth takes you on an extraordinary journey to the very edge of creation, from the moment of an egg's fertilization through each step of a human brain's development in the womb--and even a little beyond.

As pioneering experimental neurobiologist W. A. Harris guides you through the process of how the brain is built, he takes up the biggest questions that scientists have asked about the developing brain, describing many of the thrilling discoveries that were foundational to our current understanding. He weaves in a remarkable evolutionary story that begins billions of years ago in the Proterozoic eon, when multicellular animals first emerged from single-cell organisms, and reveals how the growth of a fetal brain over nine months reflects the brain's evolution through the ages. Our brains have much in common with those of other animals, and Harris offers an illuminating look at how comparative animal studies have been crucial to understanding what makes a human brain human.

An unforgettable chronicle of one of nature's greatest achievements, Zero to Birth describes how the brain's incredible feat of orchestrated growth ensures that every brain is unique, and how breakthroughs at the frontiers of science are helping us to decode many traits that only reveal themselves later in life.

Review Quotes

"[Zero to Birth] really is a masterpiece in terms of how much information is packed into this average sized book."---Nicole Barbaro, Bookmarked Reads

"Highly illuminating."---Andrew Robinson, Nature

"The story of how this development takes place is filled with as much drama as any Shakespearian plot. There are accounts of self-love and selfless cooperation, suicide and cannibalism, rivalry and survival of the fittest. All on the cellular level. And, fortunately for readers who are not experts in the field, the style makes the story comprehensible and engaging."---Gunnel Minett, Breathwork Science

"Using an expository style, interspersed with first-person accounts of his own research, Harris provides an authoritative synopsis of developmental neuroscience."---R. Douglas Fields, Science

About the Author

W. A. Harris is professor emeritus of anatomy at the University of Cambridge. A fellow of the Royal Society, he is the coauthor of Development of the Nervous System and Genetic Neurobiology and the coeditor of Retinal Development.