Super Agers - by Eric Topol (Hardcover)

About the Book

"One of the most respected, celebrated, and influential medical researchers in the world gives a guided tour of the revolution in longevity science that is exploding now. This is an evidence-based approach to longevity in a market drenched in snake oil-Eric Topol doesn't promise a silver bullet to magically stop the aging process, he shows how preventing the development of killer chronic diseases like obesity, heart disease, cancer and neurodegeneration is completely changing what "old age" can be. And we can start long before middle age-or long after. Dr. Topol shows how and why you can deal with chronic problems now instead of waiting until it is too late. Breakthrough treatments have been developed from new tools, new understanding of how our personal genomes work, and what AI can see in our health data. We can now engineer cells, build proteins and find drugs that make us live longer, better. Many of these treatments are on the shelf now-or soon will be-and improving fast. Our author is the ultimate guide because he participated in developing and testing many of them. The first part of the book "The New Age of Healthspan" describes inspiring patients aged 90+, sets out the dimensions of the new advances in the treatments of age related diseases, and details an expanded definition of what a healthy lifestyle means now-good sleep, diet, exercise, sure, but much beyond. He calls it Lifestyle+. He then turns to the "Chronic Killers"-Obesity/Diabetes, Heart Disease, Cancer, and Neurodegeneration. Parts on the "Big Collateral Implications" and "Thinking Ahead" follow and include ways we might eventually come to reverse the aging process itself"--

Book Synopsis

Super Agers is a detailed guide to a revolution transforming human longevity. This is a breakthrough moment in the history of human health care. The person making that bold claim is one of the most respected medical researchers in the world, Eric Topol.

Dr. Topol's unprecedented, evidenced-based guide is about how you and your family and friends can benefit from new treatments coming available at a faster rate than ever. From his unique position as a leader overseeing millions in research funding, Dr. Topol also explains the fundamental reasons--from semaglutides to AI--that we can be confident these breakthroughs will continue. Ninety-five percent of Americans over sixty have at least one chronic disease and almost as many have two. That is the essential problem this revolution is solving. He explains the power of the new approaches to the worst chronic killers--diabetes/obesity, heart disease, cancer, and neurodegeneration--and how treatments can begin long before middle age, and even long after. In thirty years, we will have five times as many people at least one hundred years old and they will be healthier than ever because of the breakthroughs Dr. Topol describes.

The amazing discoveries Topol brings into sharp focus are deeply inspiring about our human potential. We can now realistically see how we can make considerable headway for preventing age-related diseases and may one day be able to slow the body-wide aging process itself.

Review Quotes

"A compelling and comprehensive guide to cutting-edge treatments that rejuvenate the body, prevent diseases and enhance overall health."
--Steve Horvath, inventor of the Horvath aging clock

"Eric Topol is not only a distinguished geneticist, cardiologist, and scientist: he is the most widely read and credible health 'futurist' I know. Super Agers is a highly readable and evidence-based digest of those astonishing advances in medicine, science, and technology that directly affect our lifespans. A landmark book."
--Abraham Verghese, author of The Covenant of Water

"Imagine a world where diseases once thought incurable are treated, where we are healthier for longer. This future is getting close thanks to a radical convergence of AI and bioscience. In this gripping, vitally important and meticulously researched account, Eric Topol reveals the extraordinary breakthroughs that are transforming medicine--and our lives."
--Mustafa Suleyman, CEO of Microsoft AI

"In Super Agers, Eric Topol offers detailed insight into the factors that affect aging--and proof of AI's incredible potential to advance biomedical science, promote health, and extend longevity."
--Demis Hassabis, Nobel Laureate and CEO of Google DeepMind

"Super Agers captures the extraordinary potential of today's biomedical revolution. Eric Topol's optimistic and inspiring vision makes this book an essential guide to the future of health."
--Jennifer Doudna, Nobel Laureate, CRISPR gene editing co-inventor, and Innovative Genomics Institute founder

"A beautifully written book packed with evidence and hope. Eric Topol's vision of how AI will reduce age-related diseases is truly inspiring."
--Geoffrey Hinton, Nobel Laureate in physics for his contributions to AI

"An extraordinary book that offers a reality check as well as a blueprint for the future. Topol manages to navigate the science of aging, to distinguish it from the pseudoscience, and to provide readers an honest and measured sense of what we do and don't know. The result is a beautifully written journey into a world that is bound to change our lives."
--Siddhartha Mukherjee, author of The Emperor of All Maladies and The Song of the Cell

"Super Agers is a clear-eyed perspective on the drivers of aging from someone with a front-row seat to many of the most profound changes in healthcare and lifestyle over the past thirty years. Above all, this book is a call to action: for individuals to make changes to their lifestyle, for health professionals and scientists to explore emerging connections between different aspects of aging, and for society to make systemic changes that can benefit the health of everyone, particularly those at risk of being left behind in a new era of healthful aging."
--Feng Zhang, James and Patricia Poitras Professor of Neuroscience at MIT and Core Faculty, Broad Institute

"This eye-opening book reveals that the secret to longevity lies not in the miracle of anti-aging pills, but in groundbreaking scientific advancements. Drawing on a vast body of research, Dr. Topol shows us how modern science is paving the path toward longer, healthier lives."
--Katalin Karikó, Nobel Laureate and author of Breaking Through

"In this highly readable and engaging tour de force, Eric Topol takes on a field full of overblown or premature claims, using his personal expertise as a physician to wade through the mass of conflicting evidence to separate fact from hype and pseudoscience, and show us a path to healthy aging. People contemplating how to make the most of their lives will benefit from reading this book."
--Venki Ramakrishnan, Nobel Laureate and author of Why We Die

About the Author

Dr. Eric Topol is the executive vice president and a professor of molecular medicine at Scripps Research, the largest nonprofit biomedical institute in the United States. He is also founder and director of the Scripps Research Translational Institute and a practicing cardiologist. He is one of the top ten most cited researchers in medicine, known for his groundbreaking studies on AI in medicine, genomics, and digitized clinical trials. He was named to the Time 100 Health list of the most influential people in health in 2024. Dr. Topol writes the Substack newsletter Ground Truths and is the author of The Creative Destruction of Medicine, The Patient Will See You Now, Deep Medicine, and Super Agers.